Root canal treatment (RCT) is frequently misunderstood by some proponents of holistic dentistry who argue that systemic inflammation—purportedly linked to issues such as low birth weight in infants and erectile dysfunction—is exacerbated by dental procedures. This paper addresses one such misconception by elucidating the true rationale of endodontic treatment, introducing the “Mountain Pass Theory,” and clarifying how RCT serves to resolve, rather than cause, inflammation.
Some holistic practitioners claim that inflammation in the body can lead to systemic health issues like low birth weight or erectile dysfunction, extending this argument to include inflammation caused by dental infections such as apical periodontitis or pulpitis. However, robust research in endodontics indicates that RCT is a treatment designed to eliminate the source of inflammation rather than propagate it (Nair, 2004; Siqueira & Rôças, 2008).
The Misconception

A common misconception is that RCT can trigger further systemic inflammation. The argument suggests that by intervening in the natural pulp, the treatment may inadvertently cause bacteria or inflammatory mediators to spread throughout the body. Proponents sometimes extrapolate findings from periodontal disease research—where chronic inflammation has systemic repercussions—to RCT. In reality, while periodontal inflammation has been linked to systemic conditions (Tonetti et al., 2017), root canal treatment is aimed at eradicating the local infection and resolving the inflammatory process rather than initiating it.
Why We Do of Endodontic Treatment

The primary objective of RCT is to remove necrotic or infected pulp tissue from the tooth’s interior. This pulp tissue, once vital, can become a reservoir for bacteria and necrotic debris that contribute to local and, potentially, systemic inflammation if left untreated (Nair, 2004). By accessing and cleaning the pulp chamber and the intricate network of root canals, the treatment eliminates the source of bacteria. The canals are then disinfected and sealed, which prevents re-infection and stops the inflammatory cascade in its tracks. Notably, any inflammation that might occur post-treatment is generally associated with a failed attempt or a re-infection, not the treatment itself.
The Mountain Pass Theory
To illustrate the dynamics of infection within the tooth, the “Mountain Pass Theory” offers a vivid analogy:
- Necrotic Pulp as the Valley: Once a living pulp becomes necrotic, it houses bacterial colonies and debris, much like a valley filled with unwanted materials.
- The Apex as Mountain Peaks: The apex of the tooth’s root mimics two large mountains that create a narrow passage.
- The Root Canal as a Mountain Pass: This passage, or “mountain pass,” serves as a gateway between the infected pulp space and the body’s systemic circulation.
- The Battle at the Pass: Bacteria continuously attempt to traverse this pass. In response, the body’s immune system mounts a defense, resulting in inflammation as both sides engage in a biological battle (Siqueira & Rôças, 2008).

The only logical resolution to halt this ongoing conflict is to remove the bacterial population and necrotic debris from the root canal system—essentially closing the mountain pass to prevent further bacterial invasion. In doing so, RCT resolves the source of inflammation and contributes to both local and systemic health.
Implications for Systemic Health
While chronic inflammation from periodontal diseases has been associated with systemic conditions, effective endodontic treatment addresses and eliminates similar sources of inflammation originating from the tooth’s pulp and periapical region. By removing the infected tissue and sealing the canal, RCT prevents the systemic dissemination of inflammatory mediators and bacterial toxins. This targeted intervention is crucial for halting the immune system’s prolonged response, thereby reducing the risk of systemic complications (Tonetti et al., 2017).
It is important to note that any inflammation observed after an RCT typically results from either a failed treatment or subsequent re-infection rather than the procedure itself. When performed correctly, RCT is a safe, controlled, and effective method to manage dental infections and their potential systemic repercussions.

The misconception that root canal treatment induces systemic inflammation is unfounded. Rather than exacerbating inflammation, RCT is designed to eliminate the bacterial reservoir within the necrotic pulp tissue, effectively stopping the “mountain pass”—the pathway through which bacteria and inflammatory mediators might invade the body. Successful endodontic therapy not only preserves the tooth but also mitigates the risk of systemic complications linked to chronic oral infections.
References
- Nair, P. N. R. (2004). On the causes of persistent apical periodontitis: a review. International Endodontic Journal, 37(4), 216-225.
- Siqueira, J. F., & Rôças, I. N. (2008). Clinical implications and microbiology of bacterial persistence after treatment procedures. Journal of Endodontics, 34(4), 452-453.
- Tonetti, M. S., Jepsen, S., Jin, L., & Otomo-Corgel, J. (2017). Impact of the global burden of periodontal diseases on health, nutrition, and wellbeing of mankind: A call for global action. Journal of Clinical Periodontology, 44(5), 456-462.
